Chimowitz sammpris study

Stenting versus Aggressive Medical Therapy for ...

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for the SAMMPRIS Trial Investigators * ... Study Design and Oversight. ... Chimowitz MI, Lynn MJ, Turan TN, et al. Design of the stenting and aggressive medical management for preventing recurrent ...

Stenting versus Aggressive Medical Therapy for ...

Stenting versus Aggressive Medical Therapy for ...

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The new engl and journal of medicine n engl j med 365;11 nejm.org september 15, 2011 993 original article Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis

Stenting versus Aggressive Medical Therapy for ...

Stenting vs. Aggressive Medical Management for Preventing ...

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12/19/2007 · The purpose of this study is to compare the safety and effectiveness of either Intensive Medical Therapy PLUS Stenting or Intensive Medical Therapy ONLY in preventing stroke, heart attacks or death. The study will enroll patients over a 5 year period. Each participant will be involved in the study for a minimum of 1 year and a maximum of 3 years.

Stenting vs. Aggressive Medical Management for Preventing ...

SAMMPRIS - PubMed - NCBI

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Waters MF, Hoh BL, Lynn MJ, Kwon HM, Turan TN, Derdeyn CP, Fiorella D, Khanna A, Sheehan TO, Lane BF, Janis S, Montgomery J, Chimowitz MI; Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) Trial Investigators.. JAMA Neurol. 2016 Mar;73(3):308-15. doi: 10.1001/jamaneurol.2015.4315.

SAMMPRIS - PubMed - NCBI

SAMMPRIS: Choose aggressive meds over stenting for ...

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The study was supported by the NINDS. Chimowitz has received grants and consulting fees or honoraria from NINDS. ... Stenting pales against meds alone for intracranial stenosis: SAMMPRIS trial ...

SAMMPRIS: Choose aggressive meds over stenting for ...

Aggressive medical treatment with or without stenting in ...

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The early benefit of aggressive medical management over stenting with the Wingspan stent for high-risk patients with intracranial stenosis persists over extended follow-up. Our findings lend support to the use of aggressive medical management rather than PTAS with the Wingspan system in high-risk patients with atherosclerotic intracranial arterial stenosis.

Aggressive medical treatment with or without stenting in ...

Intracranial Angioplasty and Stenting: Current SAMMPRIS ...

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Drs. Fiorella, Derdeyn, Turan, Janis, and Chimowitz, Michael Lynn M.S, and Bethany Lane RN serve on the Executive Committee of the SAMMPRIS trial. All receive salary support from the SAMMPRIS grant. All other authors were investigators in SAMMPRIS and were reimbursed from the SAMMPRIS grant for their effort. Additional support is listed below.

Intracranial Angioplasty and Stenting: Current SAMMPRIS ...

SAMMPRIS '14 - Learnstroketrials

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Enrollment in SAMMPRIS was stopped after 451 patients had been randomized primarily because the 30-day rate of stroke and death was significantly higher in the stenting arm (Within 30 days of enrollment, stroke or death occurred in 33 patients (14.7%) in the stenting arm and in 13 (5.8%) in the medical arm; P=0.002), which lead to the ...

SAMMPRIS '14 - Learnstroketrials

SAMMPRIS Published: What Next for Intracranial Stenting?

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Both of these major findings were unexpected, lead author Marc I. Chimowitz, MB, ChB, from the Medical University of South Carolina Stroke Program in Charleston, told Medscape Medical News.

SAMMPRIS Published: What Next for Intracranial Stenting?

Relationship between risk factor control and vascular ...

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1/24/2017 · Objective: The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) study is the first stroke prevention trial to include protocol-driven intensive management of multiple risk factors. In this prespecified analysis, we aimed to investigate the relationship between risk factor control during follow-up and outcome of patients in the ...

Relationship between risk factor control and vascular ...

Rate of Postprocedural Stroke and Death in SAMMPRIS Trial ...

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2/29/2012 · The overall 30-day postprocedure stroke and death rate in our study was lower in both SAMMPRIS-eligible and -ineligible groups than the reported 14% stroke and death rate in the SAMMPRIS trial. We hypothesize that a more judicious use of primary angioplasty may be responsible for better postprocedure outcomes and should be considered an ...

Rate of Postprocedural Stroke and Death in SAMMPRIS Trial ...

The SAMMPRIS trial: the end or just the beginning ...

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12/1/2011 · The results of the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial were published recently in the New England Journal of Medicine .1 The trial was a randomized controlled trial which was sponsored by the National Institutes of Health (clinicaltrials.gov number, NCT0057693).

The SAMMPRIS trial: the end or just the beginning ...

Aggressive medical treatment with or without stenting in ...

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1/31/2014 · This study (SAMMPRIS) is the first randomised trial to compare aggressive medical management alone with aggressive medical management plus percutaneous transluminal angioplasty and stenting (PTAS) with the Wingspan stent system in patients with atherosclerotic intracranial arterial stenosis. ... SE Kasner, MI Chimowitz, MJ Lynn, et al., the ...

Aggressive medical treatment with or without stenting in ...

Type and Duration of Exercise in the SAMMPRIS Trial ...

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Request PDF on ResearchGate | Type and Duration of Exercise in the SAMMPRIS Trial | Background: Analyses from the Stenting and Aggressive Medical management for prevention of Recurrent Stroke in ...

Type and Duration of Exercise in the SAMMPRIS Trial ...

Mechanisms of Stroke After Intracranial Angioplasty and ...

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PDF | The Stenting and Aggressive Medical management for the Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial established aggressive medical management as superior to ...

Mechanisms of Stroke After Intracranial Angioplasty and ...

(PDF) Intracranial stenting SAMMPRIS - ResearchGate

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1/24/2017 · Objective: The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) study is the first stroke prevention trial to include protocol-driven intensive management of multiple risk factors. In this prespecified analysis, we aimed to investigate the relationship between risk factor control during follow-up and outcome of patients in the ...

(PDF) Intracranial stenting SAMMPRIS - ResearchGate

Relationship between risk factor control and ... - Neurology

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4/1/2014 · Objective There are few data regarding the effect of the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial results on the management of intracranial atherosclerotic disease (ICAD). We sought to understand the impact of the SAMMPRIS trial on current ICAD clinical practices and future trial design.

Relationship between risk factor control and ... - Neurology

Impact of SAMMPRIS on the future of intracranial ...

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We determined whether the stenting versus aggressive medical therapy for intracranial arterial stenosis (SAMMPRIS) trial supported this approach by comparing the treatments within subgroups of patients whose qualifying event (QE) occurred on versus off of AT.

Impact of SAMMPRIS on the future of intracranial ...

Outcome in Patients Previously on Antithrombotic Therapy ...

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SAMMPRIS. Background and Purpose—The purpose of this study was to investigate the frequency of symptomatic in-stent restenosis (ISR) and its contribution to nonprocedural symptomatic infarction in the SAMMPRIS trial (Stenting and Aggressive Medical Management for the Prevention of Recurrent Stroke in Intracranial Stenosis).

Outcome in Patients Previously on Antithrombotic Therapy ...

Nonprocedural Symptomatic Infarction and In-Stent ...

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My patient has intracranial stenosis, does he need an intracerebral stent? Results of the SAMMPRIS study Muhammad Faisal Wadiwala, Ayeesha Kamran Kamal Stroke Service and Vascular Fellowship Program, International Cerebrovascular Translational Clinical Research Training Program (Fogarty International Center

Nonprocedural Symptomatic Infarction and In-Stent ...

My patient has intracranial stenosis, does he need an ...

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The investigators note that comparisons with historical controls have limitations, but the much lower event rates in the medical group in SAMMPRIS suggest that the intensive medical management was effective in lowering the stroke risk. "The SAMMPRIS study results have immediate implications for clinical practice.

My patient has intracranial stenosis, does he need an ...

NIH stroke prevention trial has immediate implications for ...

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SAMMPRIS was funded by the NIH NINDS (Grant No.: U01NS058728) Industry Support. AstraZeneca supplied statin, and Stryker supplied Study Devices and paid for some third party monitoring visits. The SAMMPRIS trial is registered with ClinicalTrials.gov, number NCT 00576693.

NIH stroke prevention trial has immediate implications for ...

Impact of the New American Heart Association/American ...

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Chimowitz et al. Page 2 Methods—The Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis trial is an ongoing, randomized, multicenter, two-arm trial that will determine whether intracranial angioplasty and stenting adds benefit to aggressive medical management alone for preventing the primary ...

Impact of the New American Heart Association/American ...

Design of the Stenting and Aggressive Medical Management ...

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Derdeyn CP, Chimowitz MI, Lynn MJ, et al. Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.

Design of the Stenting and Aggressive Medical Management ...

UpToDate

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SAMMPRIS is aimed at evaluating whether intracranial angioplasty combined with stenting adds benefit to aggressive medical therapy for preventing stroke in patients with symptomatic intracranial arterial stenosis. The study's principal investigator is Marc I. Chimowitz, MD, …

UpToDate

Endovascular Today - NINDS Halts SAMMPRIS Trial of ...

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Patients and study design The trial design and early results are available else-where.5–7 SAMMPRIS was a randomised, superiority, multi-centre, clinical trial funded by the National Institute of Neurological Disorders and Stroke (NINDS). The US Food and Drug Administration (FDA) issued an Investigational Device Exemption to do the study with

Endovascular Today - NINDS Halts SAMMPRIS Trial of ...

Aggressive medical treatment with or without stenting in ...

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Dr. Marc Chimowitz is a neurologist in Charleston, South Carolina and is affiliated with multiple hospitals in the area, including MUSC Health-University Medical Center and Ralph H. Johnson ...

Aggressive medical treatment with or without stenting in ...

Dr. Marc Chimowitz, Neurologist in Charleston, SC | US ...

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2/7/2012 · To the Editor: The results of the prematurely terminated Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial because of the excessively high rate of stroke and death in patients randomized to intracranial stent placement is expected to affect the practice of endovascular therapy for intracranial atherosclerotic disease.

Dr. Marc Chimowitz, Neurologist in Charleston, SC | US ...

Letter to the Editor, Regarding “Prematurely Terminated ...

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Methods Study records and an investigator survey were examined for physician and site related factors, including: number of Wingspan and aneurysm stents submitted for credentialing, number of study procedures performed in SAMMPRIS, years in practice after …

Letter to the Editor, Regarding “Prematurely Terminated ...

Impact of operator and site experience on outcomes after ...

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12/19/2007 · Waters MF, Hoh BL, Lynn MJ, Kwon HM, Turan TN, Derdeyn CP, Fiorella D, Khanna A, Sheehan TO, Lane BF, Janis S, Montgomery J, Chimowitz MI; Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) Trial Investigators.

Impact of operator and site experience on outcomes after ...

Stenting vs. Aggressive Medical Management for Preventing ...

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Dr. Marc Chimowitz Countess Alicia Paolozzi SmartState Endowed Chair Stroke ... For the SAMMPRIS trial, Dr. Chimowitz received funding from the National Institutes of Health for a $20 million, 50-center nationwide clinical trial, which he led from the Medical University of South Carolina. ... The study, which was supported by one of the largest ...

Stenting vs. Aggressive Medical Management for Preventing ...

Dr. Marc Chimowitz | South Carolina Centers of Economic ...

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1/1/2015 · BACKGROUND AND PURPOSE: Middle cerebral artery stenosis is not frequent but a well-established cause of first and recurrent ischemic stroke. Our aim was to investigate middle cerebral artery stenosis in the biethnic (Jewish and Arab) population of patients with acute ischemic stroke and transient ischemic attack in northern Israel. MATERIALS AND METHODS: The study population included 1344 ...

Dr. Marc Chimowitz | South Carolina Centers of Economic ...

Middle Cerebral Artery Stenosis in Patients with Acute ...

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alizable to the SAMMPRIS study patients and thus, overestimated We do not have a complete understanding of the profile and the real risk of subsequent stroke per year in patients with symp- effect of medical risk factor control in the two treatment arms tomatic ICAD in SAMMPRIS. ... Chimowitz MI, Kokkinos J, Strong J, Brown MB, Levine SR ...

Middle Cerebral Artery Stenosis in Patients with Acute ...

Reviving Intracranial Angioplasty and Stenting "SAMMPRIS ...

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Marc I. Chimowitz, MBChB, Medical University of South Carolina Stroke Program, 19 Hagood Ave., ... The SAMMPRIS trial was funded by a research grant (U01 NS058728) from the US Public Health Service National Institute of Neurological Disorders and Stroke (NINDS). ... (formerly Boston Scientific Neurovascular) provided study devices and ...

Reviving Intracranial Angioplasty and Stenting

Response to Critique of SAMMPRIS Trial by Abou-Chebl and ...

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Derdeyn CP, Chimowitz MI, Lynn MJ, et al., on behalf of the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial Investigators. Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.

Response to Critique of SAMMPRIS Trial by Abou-Chebl and ...

Stenting and Aggressive Medical Management for Preventing ...

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Symptomatic intracranial atherosclerotic disease (ICAD) may represent the most common cause of ischemic stroke worldwide and the cause of approximately 8% to 10% of ischemic strokes in the United States [1–7]. It is a particularly important clinical entity due to the high recurrence rate of ischemic events in this population.

Stenting and Aggressive Medical Management for Preventing ...

Symptomatic Intracranial Atherosclerotic Disease | Journal ...

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Dr. Marc Chimowitz researches treatments to prevent stroke caused by narrowing of brain arteries. This field of research is especially relevant in South Carolina, which has the nation’s second-highest mortality rate from stroke. Stroke is the fourth leading cause of death in the United States.

Symptomatic Intracranial Atherosclerotic Disease | Journal ...

Marc Chimowitz | Profiles RNS

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BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.

Marc Chimowitz | Profiles RNS
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