Copernicus study rectal cancer

A trial looking at chemotherapy for people with rectal ...

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This trial looked at whether it was useful for people with cancer of the back passage (rectal cancer) to have chemotherapy before surgery. Cancer Research UK supported this trial. Radiotherapy, followed by surgery and chemotherapy is the usual treatment for rectal cancer. This is standard ...

A trial looking at chemotherapy for people with rectal ...

A prospective phase II study of pre-operative chemotherapy ...

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8/17/2018 · A prospective phase II study of pre-operative chemotherapy then short-course radiotherapy for high risk rectal cancer: COPERNICUS Skip to main content Thank you for visiting nature.com.

A prospective phase II study of pre-operative chemotherapy ...

The emerging role of neoadjuvant chemotherapy for rectal ...

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4/16/2014 · A Cochrane meta-analysis of 21 randomized controlled trials supports this practice in rectal cancer, demonstrating a 25% reduction in risk of recurrence for rectal cancer patients treated with adjuvant 5-FU based regimens . On the other hand, long term results of EORTC 22921 were recently reported . This trial employed a 2×2 factorial design ...

The emerging role of neoadjuvant chemotherapy for rectal ...

Prospective patient stratification into robust cancer‐cell ...

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COPERNICUS is a phase II study of neoadjuvant oxaliplatin‐based chemotherapy, followed by short‐course radiotherapy and surgical resection in patients with rectal cancer.

Prospective patient stratification into robust cancer‐cell ...

A Phase II study of chemotherapy given before radiotherapy ...

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A Phase II study of neoadjuvant chemotherapy given before short course of preoperative radiotherapy (SCPRT) as treatment for patients with MRI-staged operable rectal cancer at high risk of metastatic relapse Acronym. COPERNICUS Study hypothesis

A Phase II study of chemotherapy given before radiotherapy ...

A prospective phase II study of pre-operative chemotherapy ...

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A prospective phase II study of pre-operative chemotherapy then short-course radiotherapy for high risk rectal cancer: COPERNICUS. ... study, 111 patients who had rectal cancer treated by ...

A prospective phase II study of pre-operative chemotherapy ...

Total neoadjuvant therapy for rectal cancer: An emerging ...

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Nearly 40,000 rectal cancers will be diagnosed in the United States in 2016. 1 Historically, high local recurrence rates were observed despite definitive surgery for rectal cancer. 2 With improved surgical techniques and the addition of neoadjuvant radiation therapy (RT), 5‐year local recurrence rates have decreased from >25% to approximately ...

Total neoadjuvant therapy for rectal cancer: An emerging ...

Neoadjuvant Treatment Strategies for Locally Advanced ...

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Neoadjuvant Treatment Strategies for Locally Advanced Rectal Cancer. ... of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC–CTG ... SCPRT) then immediate surgery in operable rectal cancer (ORC): COPERNICUS (NCT01263171) J Clin Oncol, 33 (suppl ...

Neoadjuvant Treatment Strategies for Locally Advanced ...

Chemotherapy before surgery in the treatment of high risk ...

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9/15/2018 · This study investigated the outcomes of chemotherapy before surgery in patients with high-risk rectal cancer. Researchers suggested that chemotherapy improves tumor shrinkage before rectal surgery. Relevant for : Current disease status-First occurrence of the cancer , Current stage-Stage I, Current stage-Stage III, colorectal cancer, Research, Treatment

Chemotherapy before surgery in the treatment of high risk ...

Michal Jankowski | MD, PhD | Nicolaus Copernicus ...

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Surgical treatment of rectal cancer in Poland - A report from a prospective, multi-centre observational study PSSO_01 conducted under the auspices of the Polish Society of Surgical Oncology

Michal Jankowski | MD, PhD | Nicolaus Copernicus ...

Intestinal stoma in patients with colorectal cancer from ...

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In our study, a definitive stoma was also performed significantly more often in men and in patients with rectal cancer. It was made slightly more frequently in patients with a high stage of cancer (61.00% vs. 54.89%); however, a statistical significance was not shown.

Intestinal stoma in patients with colorectal cancer from ...

Oxaliplatin, Leucovorin, and Fluorouracil Before and After ...

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12/20/2010 · Oxaliplatin, Leucovorin, and Fluorouracil Before and After Radiation Therapy and Surgery in Treating Patients With Rectal Cancer That Can Be Removed by Surgery (COPERNICUS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Oxaliplatin, Leucovorin, and Fluorouracil Before and After ...

NOD2/CARD15 polymorphism in patients with rectal cancer ...

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Fifty-one rectal cancer patients undergoing treatment were included in the study. As a control group to provide a reference point for NOD2 polymorphism in the population, DNA obtained from cord blood collected from the placenta of 100 patients immediately after parturition was used. ... The study was approved by the Nicolaus Copernicus plays ...

NOD2/CARD15 polymorphism in patients with rectal cancer ...

An update on the multimodality of localized rectal cancer ...

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An update on the multimodality of localized rectal cancer. ... (OxMdG) Then Short-course Preoperative Radiotherapy (SCPRT) Then Immediate Surgery in Operable Rectal Cancer (ORC): COPERNICUS ... -center Randomized Controlled Trial of mFOLFOX6 with or Without Radiation in Neoadjuvant Treatment of Local Advanced Rectal Cancer (FOWARC Study ...

An update on the multimodality of localized rectal cancer ...

A prospective phase II study of pre-operative chemotherapy ...

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A prospective phase II study of pre-operative chemotherapy then short-course radiotherapy for high risk rectal cancer: COPERNICUS. Br J Cancer. ... (NAC) allows earlier treatment of rectal cancer micro-metastases but is not standard of care. There are currently no biomarkers predicting long-term progression-free survival (PFS) benefit from NAC.

A prospective phase II study of pre-operative chemotherapy ...

Long-course oxaliplatin-based preoperative chemoradiation ...

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The emerging role of neoadjuvant chemotherapy for rectal cancer Locally advanced rectal cancer remains a substantial public health problem. Historically, the disease has been plagued by high rates of both distant and local recurrences.

Long-course oxaliplatin-based preoperative chemoradiation ...

The emerging role of neoadjuvant chemotherapy for rectal ...

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Introduction. Rectal cancer is one of the most commonly diagnosed malignancies and the burden of the disease is expected to increase by more than half in 2030. 1 Total mesorectal excision (TME) was originally performed as an open procedure; however, over time the laparoscopic approach to the TME (LaTME) has become more prevalent, and in some cases, preferred. 2 This approach has been ...

The emerging role of neoadjuvant chemotherapy for rectal ...

BMS JOURNALS - bhmedsoc.com

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7/1/2013 · Recently, the MERCURY group published data suggesting that an MRI-assessed tumor regression grade (mrTRG) based on the degree of low signal intensity appearances of fibrosis can predict for improved outcomes following CRT in patients with rectal cancer. In this study, the 5-year survival rate for patients with poor mrTRG was 27% compared with ...

BMS JOURNALS - bhmedsoc.com

Selecting Patients With Locally Advanced Rectal Cancer for ...

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Randomised trials with neoadjuvant systemic therapy are in progress (eg, Rapido, Prospect, Prodige 23, Copernicus, Bacchus, Steve Gschmeissner/Science Photo Library and a trial from the Polish Colorectal Cancer Study Group).

Selecting Patients With Locally Advanced Rectal Cancer for ...

Adjuvant chemotherapy for rectal cancer still ...

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2/23/2012 · This study demonstrated an overall pCR rate of 7/20 (35%) and 2/6 rectal cancer patients (33%) without metastases . A feasibility study tested a NACT approach in patients with clinical stage II–III rectal cancer (but not T4 tumours), who were considered candidates for sphincter-sparing surgery . The primary outcome was the R0 resection rate.

Adjuvant chemotherapy for rectal cancer still ...

Neoadjuvant chemotherapy in MRI-staged high-risk rectal ...

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Assessment of psychosocial aspects of patients with rectal cancer under chemotherapy in Baghdad city ... Objectives The study objectives are to determine and identify the association between the effect of chemotherapy upon psychological andsocial aspects of the quality of life for patients with rectal cancer treated by chemotherapy and ...

Neoadjuvant chemotherapy in MRI-staged high-risk rectal ...

Assessment of psychosocial aspects of patients with rectal ...

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The CAIRO4 study: The role of surgery of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastases of colorectal cancer—A randomized phase III study of the Dutch Colorectal Cancer Group (DCCG).

Assessment of psychosocial aspects of patients with rectal ...

Colorectal Cancer | 2015 ASCO Annual Meeting | Abstracts ...

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association with colon cancer [9, 11–15]. XRCC3-241Thr genotype was associated with adverse progression-free survival of colorectal cancer patients in one study [13]. This polymorphism was also associated with a better prognosis for colorectal cancer patients [14]. A …

Colorectal Cancer | 2015 ASCO Annual Meeting | Abstracts ...

Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the ...

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12/1/2012 · 112 patients with primary rectal cancer were enrolled in this study. 42 patients were treated with a gentamicin sponge and drainage (group A) and 70 individuals were treated with drainage alone (group B). In the aforementioned groups a routine short-term regimen of antibiotic prophylaxis was used.

Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the ...

Local Antibiotic Therapy in Rectal Cancer Surgery : Polish ...

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Key words: rectal cancer, preoperative chemoradiation introduction Tumour excision may not always be possible in treating advanced cT3 or cT4 rectal cancers and the likelihood of R1-2 resection is high. Preoperative long-course chemoradiation, aimed at tumour shrinkage, is used to achieve R0 resection.

Local Antibiotic Therapy in Rectal Cancer Surgery : Polish ...

Long-course oxaliplatin-based preoperative chemoradiation ...

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noses in colorectal cancer. In this study, we explored the association between the NLR and prognoses follow- ... Chemical Abstracts/CAS Index Copernicus CLINICAL RESEARCH ... Background Along with colon cancer, rectal cancer is the second leading cause of cancer-associated deaths in the U.S. with about 40,000 newly diagnosed cases in 2014 [1 ...

Long-course oxaliplatin-based preoperative chemoradiation ...

Prognostic Role of Neutrophil-to-Lymphocyte Ratio in ...

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This single-arm phase II study evaluated neoadjuvant chemotherapy followed by short-course radiotherapy prior to surgery for patients with operable rectal cancer. Compliance was better with neoadjuvant vs adjuvant chemotherapy. Treatment intensity was higher in …

Prognostic Role of Neutrophil-to-Lymphocyte Ratio in ...

Preoperative Chemotherapy Followed by Short-Course ...

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The EORTC 22921 study was conducted in 9 European countries and Israel, and involved 1011 patients with clinical stage T3 or T4 resectable rectal cancer who were treated with preoperative ...

Preoperative Chemotherapy Followed by Short-Course ...

Adjuvant Chemo in Rectal Cancer: Question ... - Medscape

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Study Design A Data Collection B Statistical Analysis C Data Interpretation D ... Chemical Abstracts/CAS Index Copernicus This work is licensed under a Creative Commons ... the standard therapy for locally advanced rectal cancer and its application is increasing in other cancers, such as esoph-ageal cancer and gastric cancer [1]. However, the ...

Adjuvant Chemo in Rectal Cancer: Question ... - Medscape

Accepted: 2015.09.16 Received: 2015.07.23 MTHFR C677T ...

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The proportion of tumour cells is an independent predictor for survival in colorectal cancer patients.

Accepted: 2015.09.16 Received: 2015.07.23 MTHFR C677T ...

The proportion of tumour cells is an independent predictor ...

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To investigate these two issues, we performed a retrospective case-control study in Chinese patients with metastatic colorectal cancer. Patients initially diagnosed as metastatic colorectal cancer at the Sun Yat-sen University Cancer Center from 2004 to 2010 were recruited.

The proportion of tumour cells is an independent predictor ...

Colorectal Cancer Top Open Access Journals

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PubFacts seeks to make the world's scientific research easy to locate, access, and collaborate on.

Colorectal Cancer Top Open Access Journals

Rectal screening Publications | PubFacts

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copernicus-sagres sagres Home treatment for rectal itching depends on the cause of the Rectal Problems - Home Treatment. improves the level of glucose. Glutathione peroxidase is an enzyme which reduced lipid hydroperoxides into their corresponding alcohols.

Rectal screening Publications | PubFacts

Glutathione In Turmeric C For Dose Cold / copernicus ...

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This study was designed to compare and evaluate the presence of engrailed-2 (EN2) protein in urine c

Glutathione In Turmeric C For Dose Cold / copernicus ...

Engrailed-2 protein as a potential urinary prostate cancer ...

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Index Copernicus Value: 62.73. Chemotherapy: Open Access (CMT) deals with various types of therapeutic techniques such as Cytotoxic, Electro, and the antimicrobial chemotherapies used to treat several dreadful diseases, particularly Cancer.

Engrailed-2 protein as a potential urinary prostate cancer ...

Chemotherapy: Open Access- Open Access Journals

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Diabetes again linked to colon cancer risk: study

Chemotherapy: Open Access- Open Access Journals

Diabetes again linked to colon cancer risk: study

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In recent years, neoadjuvant chemoradiotherapy (CRT) has become the standard of care for patients with locally advanced rectal cancer. Until recently, patients routinely proceeded to surgical resection after CRT, regardless of the response. Nowadays, treatment is tailored depending on the response to chemoradiotherapy.

Diabetes again linked to colon cancer risk: study
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