Hapo study conclusions

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study

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8/14/2008 · The objective of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study was to clarify the risk of adverse outcome associated with degrees of glucose intolerance during pregnancy that are less severe than overt diabetes.

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study

The HAPO Study: Paving The Way For New Diagnostic Criteria ...

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The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study was performed in response to the need for internationally agreed upon diagnostic criteria for gestational diabetes, based upon their predictive value for adverse pregnancy outcome. Increases in each of the three values on the 75 gram, 2 ...

The HAPO Study: Paving The Way For New Diagnostic Criteria ...

Hyperglycemia and Adverse Pregnancy Outcomes | NEJM

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Background It is controversial whether maternal hyperglycemia less severe than that in diabetes mellitus is associated with increased risks of adverse pregnancy outcomes. Methods A total of 25,505 ...

Hyperglycemia and Adverse Pregnancy Outcomes | NEJM

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The new england journal medicine - nejm.org

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n engl j med 358;19 www.nejm.org may 8, 2008 1991 The new england journal of medicine established in 1812 may 8, 2008 vol. 358 no. 19 Hyperglycemia and Adverse Pregnancy Outcomes The HAPO Study ...

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Hyperglycemia and Adverse Pregnancy Outcome Follow-up ...

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3/1/2019 · OBJECTIVE Whether hyperglycemia in utero less than overt diabetes is associated with altered childhood glucose metabolism is unknown. We examined associations of gestational diabetes mellitus (GDM) not confounded by treatment with childhood glycemia in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. RESEARCH DESIGN AND METHODS HAPO Follow-up Study …

Hyperglycemia and Adverse Pregnancy Outcome Follow-up ...

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Gestational diabetes and pregnancy outcomes - a systematic ...

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3/31/2012 · Two criteria based on a 2 h 75 g OGTT are being used for the diagnosis of gestational diabetes (GDM), those recommended over the years by the World Health Organization (WHO), and those recently recommended by the International Association for Diabetes in Pregnancy Study Group (IADPSG), the latter generated in the HAPO study and based on pregnancy outcomes.

Gestational diabetes and pregnancy outcomes - a systematic ...

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Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study ...

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OBJECTIVE— To examine associations of neonatal adiposity with maternal glucose levels and cord serum C-peptide in a multicenter multinational study, the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study, thereby assessing the Pederson hypothesis linking maternal glycemia and fetal hyperinsulinemia to neonatal adiposity. RESEARCH DESIGN AND METHODS— Eligible pregnant …

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study ...

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study ...

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OBJECTIVE - To compare associations of maternal glucose and A1C with adverse outcomes in the multinational Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and determine, based on those comparisons, if A1C measurement can provide an alternative to an oral glucose tolerance test (OGTT) in pregnant women.

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study ...

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Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study

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Objective—To compare associations of maternal glucose and A1C with adverse outcomes in the multinational Hyperglycemia and Adverse Pregnancy Outcome …

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study

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Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study ...

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Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: Common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the International Association of Diabetes and Pregnancy Study Groups.

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study ...

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study ...

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PDF | Objective: To examine associations of neonatal adiposity with maternal glucose levels and cord serum C-peptide in a multicenter multinational study, the Hyperglycemia and Adverse Pregnancy ...

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study ...

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Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study

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The protocol was approved by the institutional review board at all 15 field centers. All participants gave written informed consent. An external data monitoring committee provided oversight. Study ...

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study

The Hyperglycemia and Adverse Pregnancy Outcome (HAPO ...

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Objective: The objective of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study is to clarify unanswered questions on associations of maternal glycemia, less severe than overt diabetes mellitus, with risks of adverse pregnancy outcome. This report describes the background and design of the HAPO Study. Methods: HAPO is a 5-year investigator-initiated prospective observational study ...

The Hyperglycemia and Adverse Pregnancy Outcome (HAPO ...

The Hyperglycemia and Adverse Pregnancy Outcome (HAPO ...

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The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study was performed in response to the need for internationally agreed upon diagnostic criteria for gestational diabetes, based upon their predictive value for adverse pregnancy outcome.

The Hyperglycemia and Adverse Pregnancy Outcome (HAPO ...

Maternal BMI, Peripheral Deiodinase Activity, and Plasma ...

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Identify fasting plasma samples and selected demographic, biophysical, and biochemical data from a subset of 600 randomly selected non-Hispanic Caucasian women recruited in the Hyperglycemia Adverse Pregnancy Outcomes (HAPO) study, all with glucose tolerance testing [545 samples sufficient to measure thyrotropin (TSH), free thyroxine (fT4), and triiodothyronine (T3)].

Maternal BMI, Peripheral Deiodinase Activity, and Plasma ...

Hyperglycemia and adverse pregnancy outcomes (HAPO)

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Hyperglycemia and adverse pregnancy outcomes (HAPO) ... Conclusions We observed a high heterogeneity among the studies. ... (HAPO) Study is to clarify unanswered questions on …

Hyperglycemia and adverse pregnancy outcomes (HAPO)

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Screening and diagnosis of gestational diabetes mellitus ...

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6/1/2016 · Gestational diabetes mellitus (GDM) is one of the most common metabolic complications of pregnancy. Ever since the first systematic evaluation of the oral glucose tolerance test by O’Sullivan and colleagues was carried out in 1964, there has been controversy with respect to the optimal screening and diagnostic criteria to detect GDM. The recently proposed International Association of ...

Screening and diagnosis of gestational diabetes mellitus ...

Maternal glucose levels during pregnancy and childhood ...

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cose [4]. The HAPO Follow-up Study (HAPO FUS) offered a unique opportunity to examine associations of maternal glu-cose levels during pregnancy with childhood adiposity, not confounded by treatment of maternal hyperglycaemia. We re-cently reported that, while GDM based on International Association of Diabetes in Pregnancy Study Groups

Maternal glucose levels during pregnancy and childhood ...

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study

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OBJECTIVE--To compare associations of maternal glucose and A1C with adverse outcomes in the multinational Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and determine, based on those comparisons, if A1C measurement can provide an alternative to an oral glucose tolerance test (OGTT) in pregnant women.

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study

Historical facts of screening and diagnosing diabetes in ...

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5/1/2013 · The HAPO Study cooperative research group. N Engl J Med. 2008, 358: 1991-2002. View Article PubMed Google Scholar; International Association of Diabetes and Pregnancy Study Groups Consensus Panel: International Association of Diabetes and Pregnancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in Pregnancy.

Historical facts of screening and diagnosing diabetes in ...

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Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study ...

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10/1/2010 · Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Common Genetic Variants in GCK and TCF7L2 Are Associated With Fasting and Postchallenge Glucose Levels in Pregnancy and With the New Consensus Definition of Gestational Diabetes Mellitus From the International Association of Diabetes and Pregnancy Study Groups

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study ...

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Pregnancy outcomes in women with gestational diabetes ...

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5/10/2018 · The World Health Organization (WHO) adopted more stringent diagnostic criteria for GDM in 2013, to improve pregnancy outcomes. However, there is no global consensus on these new diagnostic criteria, because of limited evidence. The objective of the study was to evaluate maternal characteristics and pregnancy outcomes in two cohorts in the Netherlands applying different diagnostic criteria for ...

Pregnancy outcomes in women with gestational diabetes ...

IADPSG Criteria May Improve Diagnosis of Gestational ...

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Among 25,505 HAPO study participants, 6,159 blinded participants from North American centers were included. Of these, 81% had normal glucose testing, 4.2% had GDM based on CC criteria, and 14.3% had GDM based on IADPSG criteria but not CC criteria.

IADPSG Criteria May Improve Diagnosis of Gestational ...

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Integration of local and central laboratory functions in a ...

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Purpose To describe the challenges and the approach to meeting them in measuring glucose, HbA1c, and C-peptide in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. HAPO is an observational epidemiologic study of 25 000 pregnant women from 15 centres in 10 countries, designed to clarify unanswered questions on associations of ...

Integration of local and central laboratory functions in a ...

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Diagnostic Criteria and Classification of Hyperglycaemia ...

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Pregnancy Outcome (HAPO) study - proposes a new classification for hyperglycaemia first detected in pregnancy - removes the ambiguity with regard to fasting plasma glucose values in the 1999 WHO guideline - clarifies ambiguities in the IADPSG criteria related to ranges of plasma glucose values for distinguishing diabetes in pregnancy and GDM.

Diagnostic Criteria and Classification of Hyperglycaemia ...

Categorisation of continuous exposure variables revisited ...

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11/9/2010 · Although the general statistical advice is to keep continuous exposure variables as continuous in statistical analyses, categorisation is still a common approach in medical research. In a recent paper from the Hyperglycaemia and Adverse Pregnancy Outcome (HAPO) Study, categorisation of body mass index (BMI) was used when analysing the effect of BMI on adverse pregnancy outcomes.

Categorisation of continuous exposure variables revisited ...
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